8,14 % | The Vanguard Group, Inc. | 22.764.739 | 669.350 | 31/12/2023 |
7,15 % | MHR Fund Management LLC | 19.997.103 | 0 | 31/12/2023 |
6,87 % | Perceptive Advisors LLC | 19.221.743 | 7.242.328 | 20/2/2024 |
6,04 % | BlackRock Institutional Trust Company, N.A. | 16.898.233 | 680.727 | 31/12/2023 |
5,87 % | State Street Global Advisors (US) | 16.424.388 | -307.881 | 31/12/2023 |
2,39 % | Avoro Capital Advisors LLC | 6.700.000 | 0 | 31/12/2023 |
10,03 % | Quogue Capital L.L.C. | 28.067.333 | 5.000.000 | 20/2/2024 |
1,88 % | Pictet Asset Management Ltd. | 5.263.309 | -1.650.375 | 31/12/2023 |
1,80 % | Geode Capital Management, L.L.C. | 5.037.098 | 287.687 | 31/12/2023 |
1,73 % | Artisan Partners Limited Partnership | 4.827.670 | -208.809 | 31/12/2023 |
1,68 % | OrbiMed Advisors, LLC | 4.707.458 | 0 | 31/12/2023 |
1,40 % | Balyasny Asset Management LP | 3.926.159 | -550.677 | 31/12/2023 |
1,26 % | Dimensional Fund Advisors, L.P. | 3.516.987 | -461.398 | 31/12/2023 |
1,18 % | BioImpact Capital LLC | 3.289.470 | 2.073 | 31/12/2023 |
1,13 % | T. Rowe Price Associates, Inc. | 3.153.086 | -318.633 | 31/12/2023 |
1,05 % | Morgan Stanley & Co. LLC | 2.926.065 | 929.531 | 31/12/2023 |
1,00 % | Goldman Sachs & Company, Inc. | 2.811.932 | -161.559 | 31/12/2023 |
0,94 % | Principal Global Investors (Equity) | 2.636.327 | -6.828 | 31/12/2023 |
0,91 % | Credit Suisse Funds AG | 2.557.380 | -2.533 | 31/12/2023 |
0,76 % | Long Focus Capital Management LLC | 2.135.521 | -335.000 | 31/12/2023 |
0,75 % | Palo Alto Investors LP | 2.106.792 | 2.106.792 | 31/12/2023 |
0,72 % | Hood River Capital Management LLC | 2.001.510 | 9.175 | 31/12/2023 |
0,70 % | Northern Trust Investments, Inc. | 1.954.979 | 183.827 | 31/12/2023 |
0,63 % | Rice Hall James & Associates, LLC | 1.750.907 | 28.196 | 31/12/2023 |
0,63 % | 683 Capital Management LLC | 1.750.000 | -300.000 | 31/12/2023 |
0,62 % | Charles Schwab Investment Management, Inc. | 1.747.023 | 54.490 | 31/12/2023 |
0,62 % | Candriam Belgium S.A. | 1.727.822 | -1.020.031 | 31/12/2023 |
0,60 % | Candriam Luxembourg S.A. | 1.692.770 | 0 | 29/2/2024 |
0,57 % | Woodline Partners LP | 1.604.706 | 958.411 | 31/12/2023 |
0,57 % | JPMorgan Asset Management U.K. Limited | 1.602.777 | -44.401 | 31/12/2023 |
0,57 % | Susquehanna International Group, LLP | 1.598.930 | 353.893 | 31/12/2023 |
0,54 % | DWS Investments UK Limited | 1.524.812 | 1.412.125 | 31/12/2023 |
0,50 % | Boxer Capital, L.L.C. | 1.400.000 | -2.305.133 | 31/12/2023 |
0,49 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 1.360.000 | 0 | 31/12/2023 |
0,45 % | Rafferty Asset Management LLC | 1.247.515 | -248.655 | 31/12/2023 |
0,40 % | Norges Bank Investment Management (NBIM) | 1.120.457 | -1.854.400 | 31/12/2023 |
0,40 % | Rhenman & Partners Asset Management AB | 1.116.818 | 166.818 | 31/12/2023 |
0,38 % | Invenomic Capital Management LP | 1.053.251 | -42.946 | 31/12/2023 |
0,37 % | New York State Common Retirement Fund | 1.021.824 | -5.141 | 31/12/2023 |
0,37 % | Schonfeld Strategic Advisors LLC | 1.021.818 | 1.021.818 | 31/12/2023 |
0,36 % | Tang Capital Management, LLC | 1.000.000 | 1.000.000 | 31/12/2023 |
0,35 % | Voloridge Investment Management, LLC | 983.080 | 782.656 | 31/12/2023 |
0,34 % | Millennium Management LLC | 939.546 | -6.880.528 | 31/12/2023 |
0,33 % | BofA Global Research (US) | 936.887 | -293.181 | 31/12/2023 |
0,33 % | Nuveen LLC | 930.818 | -638.955 | 31/12/2023 |
0,33 % | JP Morgan Asset Management | 926.109 | -63.353 | 31/12/2023 |
0,32 % | Opaleye Management Inc. | 897.000 | 287.000 | 31/12/2023 |
0,31 % | BlackRock Financial Management, Inc. | 859.954 | -119.170 | 31/12/2023 |
0,31 % | T. Rowe Price Investment Management, Inc. | 858.100 | 858.100 | 31/3/2024 |
0,31 % | UBS Financial Services, Inc. | 857.308 | 618.755 | 31/12/2023 |
0,30 % | Goldman Sachs Asset Management, L.P. | 845.818 | 66.388 | 31/12/2023 |
0,30 % | Barclays Bank PLC | 836.175 | 78.243 | 31/12/2023 |
0,28 % | Banque Pictet & Cie S.A. | 778.038 | 144.244 | 31/12/2023 |
0,27 % | Pictet Asset Management (Japan) Ltd. | 746.057 | 279.233 | 31/10/2023 |
0,26 % | Citi Investment Research (US) | 721.210 | -182.340 | 31/12/2023 |
0,25 % | Brevan Howard Capital Management LP | 692.775 | -869.911 | 31/12/2023 |
0,24 % | QVT Financial LP | 678.564 | 0 | 31/12/2023 |
0,24 % | Cutter Capital Management, LP | 677.350 | 677.350 | 31/12/2023 |
0,23 % | Vivo Capital, LLC | 655.057 | 0 | 31/12/2023 |
0,23 % | Invesco Capital Management LLC | 652.170 | 570.056 | 31/12/2023 |
0,23 % | Laurion Capital Management LP | 637.742 | 637.742 | 31/12/2023 |
0,22 % | BlackRock Investment Management, LLC | 615.971 | 22.555 | 31/12/2023 |
0,22 % | BNY Mellon Asset Management | 602.181 | 4.931 | 31/12/2023 |
0,21 % | Parametric Portfolio Associates LLC | 578.893 | 268.044 | 31/12/2023 |
0,21 % | Group One Trading, L.P. | 576.302 | -49.399 | 31/12/2023 |
0,20 % | Farallon Capital Management, L.L.C. | 562.000 | 562.000 | 31/12/2023 |
0,20 % | McPeak (Merrill A) | 558.783 | 250.000 | 20/2/2024 |
0,20 % | Soleus Capital Management, L.P. | 555.000 | -684.777 | 31/12/2023 |
0,20 % | BNP Paribas Securities Corp. North America | 552.847 | 251.536 | 31/12/2023 |
0,19 % | Jane Street Capital, L.L.C. | 522.561 | -27.354 | 31/12/2023 |
0,18 % | Zimmer Partners, LP | 495.000 | -93.000 | 31/12/2023 |
0,17 % | Cubist Systematic Strategies, LLC | 468.821 | 468.821 | 31/12/2023 |
0,16 % | Eagle Asset Management, Inc. | 450.456 | 450.456 | 31/12/2023 |
0,16 % | International Biotechnology Trust PLC | 445.000 | 380.000 | 30/9/2023 |
0,16 % | Schweizerische Nationalbank | 439.456 | -49.900 | 31/12/2023 |
0,15 % | Hennion & Walsh Asset Management, Inc. | 407.429 | 121.395 | 31/3/2024 |
0,14 % | Medical Strategy GmbH | 393.779 | 0 | 30/9/2023 |
0,14 % | DWS Investment GmbH | 390.600 | 0 | 31/12/2023 |
0,14 % | Arctic Fund Management AS | 385.029 | -12.100 | 29/2/2024 |
0,13 % | Simplex Trading, LLC | 374.067 | 198.650 | 31/12/2023 |
0,13 % | Rhumbline Advisers Ltd. Partnership | 368.456 | 16.289 | 31/12/2023 |
0,13 % | Corient Private Wealth LLC | 367.000 | 247.199 | 31/12/2023 |
0,12 % | PanAgora Asset Management Inc. | 346.190 | 12.216 | 31/12/2023 |
0,12 % | American Century Investment Management, Inc. | 333.136 | -75.622 | 31/12/2023 |
0,12 % | Lombard Odier Asset Management (Europe) Ltd | 331.776 | -71.654 | 30/9/2022 |
0,12 % | Schroder Investment Management Ltd. (SIM) | 324.736 | 324.736 | 31/12/2023 |
0,11 % | Parametrica Management Ltd | 320.276 | 224.876 | 31/12/2023 |
0,11 % | BlackRock Advisors (UK) Limited | 314.282 | 22.423 | 31/3/2024 |
0,11 % | Stifel, Nicolaus & Company, Incorporated | 307.754 | 77.600 | 31/12/2023 |
0,11 % | Nomura Asset Management Co., Ltd. | 305.301 | 9.002 | 30/11/2023 |
0,11 % | HRT Financial LP | 294.763 | 294.763 | 31/12/2023 |
0,10 % | Citadel Advisors LLC | 286.034 | -103.101 | 31/12/2023 |
0,10 % | Hudson Bay Capital Management LP | 275.000 | -155.200 | 31/12/2023 |
0,10 % | Wells Fargo Advisors | 274.287 | 70.093 | 31/12/2023 |
0,09 % | Manulife Investment Management (North America) Limited | 264.971 | 1.042 | 31/12/2023 |
0,09 % | Driehaus Capital Management, LLC | 257.959 | 257.959 | 29/2/2024 |
0,09 % | TD Asset Management Inc. | 257.460 | -78.618 | 31/12/2023 |
0,09 % | Credit Suisse International | 256.936 | -26.620 | 31/12/2023 |
0,09 % | AllianceBernstein L.P. | 252.890 | -90.300 | 31/12/2023 |
0,09 % | CM Management, LLC | 250.000 | 50.000 | 31/12/2023 |